Louisville defeated Kentucky 41–0 in a dominant performance. Louisville covered by 42.5; Game went Under by 4.5.

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At kick-off, conditions at L&N Federal Credit Union Stadium were Overcast, 34.3°F, Wind Chill 25.3°F with winds of 8.5 mph. At 34.3°F, cold conditions may be a minor factor in this game. Historical weather data for this game is preserved in the panel below.
34.3°F
Despite missing top three running backs, true freshman walk-on Braxton Jennings (113 yards) and redshirt freshman Shaun Boykins Jr. (101 yards, TD) each rushed for over 100 yards, leading a 258-yard ground game that was Louisville's second-best of the season.
Quarterback Miller Moss, returning from a foot injury, completed 12 of 20 passes for 182 yards and accounted for four touchdowns (three passing, one rushing), providing a steady hand for the offense.
Louisville's defense held Kentucky to a season-low 147 yards, forced two turnovers, and allowed only 2-of-14 third-down conversions. A blocked punt in the first quarter set up the opening score, showcasing a complete team effort.
The 41-0 victory was Louisville's largest margin of win in the series since 1994 and their first shutout of Kentucky in 21 years, snapping a three-game losing streak and providing a major morale boost.
Louisville improved to 8-4 and will play in a bowl game (destination announced Dec. 7). The blowout win gives the Cardinals a chance to win at least nine games for the third straight season, building confidence despite key injuries.
Kentucky travels 69 miles to this game, a short road trip.
Louisville won by 41 in a dominant performance.
Louisville covered the spread comfortably.
The total went Under by 4.5 points.
At 34.3°F, cold conditions may be a minor factor in this game.
Full conditions are shown in the data panel above. Forecast data sourced from WeatherAPI.com. Use the Line Value Calculator to apply a manual weather adjustment to your projected line.
Blue Chip Analytics power ratings favour Louisville (18.4) over Kentucky (7.5) by 10.9 points on a neutral field. After adding home field advantage, the rating-implied line may differ meaningfully from the market spread. Louisville brings one of the stronger home environments in the FBS to this matchup (Blue Chip HFA: 3.2). Add this to the neutral-site differential to arrive at a venue-adjusted line.
Blue Chip Analytics power ratings represent expected point margin against an average FBS opponent on a neutral field, calculated from game data sourced via CollegeFootballData.com (CFBD). They are one input: cross-reference with the travel, rest, and weather data above before drawing conclusions.
Louisville won and Louisville covered the spread.