JC French IV takes over at QB after Brendan Sorsby's departure. The offense will lean heavily on the run game with Zion Johnson, Gi'Bran Payne, and Zylan Perry, using play-action passes. French's comfort in this system is critical, especially against a Boston College defense that will likely test his decision-making early.

First-year DC Nate Woody's pressure-based 3-3-5 scheme aims to force more turnovers after last season's low numbers. Key additions like Josh Hough, Chidera Otutu, and Filip Maciorowski should create chaos, but the unit must gel quickly against a Boston College offense that may try to exploit early miscommunications.

Cincinnati opens at home with a 2.5-point HFA boost. The forecast calls for partly cloudy skies, 64°F, and 13 mph wind, which could affect passing accuracy and kicking. The Bearcats' strong running game and experienced offensive line may benefit from these conditions, while the defense's pass rush could be aided by the wind.

The wide receiver room is almost entirely new, with Isaiah Johnson as the primary deep threat. JV Gibson, Larenzo Fenner, and Cade Wolford must step up. If the running game stalls or French faces pressure, the passing game's lack of chemistry could be a liability against Boston College's secondary.

Returning kicker Stephen Rusnak and punter Max Fletcher provide reliability in a game that could be close. Isaiah Johnson's speed on returns adds a big-play threat. In windy conditions, field position and kicking accuracy become even more important, giving Cincinnati a potential advantage.

Iowa State lost over 50 players to the portal, including 16 starters and 24 who followed the former coach to Penn State. The team added more than 45 transfers, meaning nearly the entire roster is new. This lack of continuity could lead to early-season execution issues, especially on offense where the line is almost entirely rebuilt and the quarterback is a newcomer.

Offensive coordinator Tyler Roehl, returning from the Detroit Lions, is expected to emphasize downhill rushing and play-action passing. The running back duo of Aiden Flora and MAC Freshman of the Year Cameron Pettaway provides a strong foundation, but the rebuilt offensive line must gel quickly for the scheme to work effectively.

The defense returns several contributors like DL Zaimir Hawk and Jace J. Gilbert, LB Carson Willich, and DBs David Coffey and Drew Surges. However, the spring ACL injury to Toledo transfer safety Braden Awls is a significant blow, forcing the staff to develop replacements during the summer. The unit's depth and chemistry will be tested early.

Kicker Kyle Konrardy is one of the nation's best, and the return game features explosive threats in Pettaway (33.0-yard kickoff return average) and Flora (26.1-yard punt return average with a touchdown). In a game where the offense may need time to click, special teams could provide crucial field position and scoring.

Iowa State hosts Southeast Missouri State at home with a 2.7-point home-field advantage. The forecast calls for partly cloudy skies at 69°F but with 23 mph wind, which could affect passing and kicking. The Cyclones' run-heavy offensive approach may be well-suited to these conditions, while the defense must account for wind on deep throws.